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New study on development of Parkinson's disease is 'on the nose'
on August 3, 2020 at 1:21 pm
Scientists suggest that the initial impact of environmental toxins inhaled through the nose may induce inflammation in the brain, triggering the production of Lewy bodies that can then be spread to other brain regions. However, the relationship linking olfactory dysfunction and Parkinson's disease development remains unclear. New findings from a study add weight to this theory and identify a critical signaling molecule that may be key to the domino effect kicked off by nasal inflammation.
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Neuronal circuits in the brain 'sense' our inner state
on July 15, 2020 at 3:14 pm
How decisions are made and how behavior is controlled is one of the most important questions in neuroscience. The neurotransmitter dopamine plays a central role in all of this. Scientists looked into the role that dopamine plays in the decision-making process and in controlling movement.
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One-time treatment generates new neurons, eliminates Parkinson's disease in mice
on June 25, 2020 at 2:25 pm
Researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice's Parkinson's disease symptoms disappear.
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Disrupted circadian rhythms linked to later Parkinson's diagnoses
on June 15, 2020 at 6:28 pm
Older men who have a weak or irregular circadian rhythm guiding their daily cycles of rest and activity are more likely to later develop Parkinson's disease, according to a new study.
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Solving a Parkinson's disease puzzle through protein design
on June 11, 2020 at 1:41 pm
Scientists have developed a computational protein design approach, and used it to obtain the first ever high-resolution structure of an activated dopamine receptor in its natural cell membrane environment. The breakthrough will open up a new dimension in drug discovery for Parkinson's disease and perhaps other disorders.