Researchers say they have added to evidence that the compound farnesol, found naturally in herbs, and berries and other fruits, prevents and reverses brain damage linked to Parkinson's disease in mouse studies.
For decades, a key brain area has been thought to merely regulate locomotion. Now, a research group has shown that the region is involved in much more than walking, as it contains distinct populations of neurons that control different body movements. The findings could help to improve certain therapies for Parkinson's disease.
Researchers have found that a component derived from turmeric essential oil, ar-turmerone, and its derivatives act directly on dopaminergic neurons to exert a neuroprotective effect on tissue cultures of a Parkinson's disease model. The effect appears to be due to the enhancement of cellular antioxidant potency through Nrf2 activation. The researchers believe that the ar-turmerone derivatives identified in this study can be utilized as new therapeutic agents for Parkinson's disease.