Researchers have discovered that the genetic variant APOE4 -- long linked to dementia -- spurs the spread of harmful clumps of Parkinson's proteins through the brain. The findings suggest that therapies that target APOE might reduce the risk of dementia for people with Parkinson's disease.
Biomedical scientists have discovered that a defect in the ATP13A2 gene causes cell death by disrupting the cellular transport of polyamines. When this happens in the part of the brain that controls body movement, it can lead to Parkinson's disease.
People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new research. The research points to a drug that potentially might help correct these disease processes.