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- Scientists discover key to preventing neurodegeneration in Parkinson's and related disorderson November 1, 2024 at 4:37 pm
A team of researchers has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease. The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of alpha-synuclein, a protein associated with neurodegeneration. By demonstrating that inhibiting G4 assembly could potentially prevent the onset of synucleinopathies, this discovery positions G4 as a promising target for early intervention in these diseases.
- Antibiotics and antifungals may slightly affect Parkinson's risk, study findson October 23, 2024 at 6:19 pm
Research highlights a complex relationship between bacteria in the digestive tract and brain health.
- Recreating a hallmark of Parkinson's disease in human neuronson October 8, 2024 at 2:38 pm
Scientists have recreated the growth of Lewy bodies in human neurons and followed their formation to gain important insight into why and how they form. Critically, they find that immune challenge is important for this process, identifying a previously unknown link between the immune system and neurological disease.
- Role of ophthalmic acid in motor function controlon October 4, 2024 at 7:36 pm
A research team has revealed that a molecule in the brain -- ophthalmic acid -- unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's and other movement diseases.
- A risky business: Why do some Parkinson's disease treatments affect decision making?on September 24, 2024 at 4:29 pm
Parkinson's disease, a debilitating nervous system disorder, is treated with medications that sometimes cause impaired decision-making and poor impulse control. Now, researchers have identified a structure in the brain called the external globus pallidus which may be responsible for this side effect, paving the way for new treatments.