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- Immune cells in the brain share the workon September 22, 2021 at 5:30 pm
To break down toxic proteins more quickly, immune cells in the brain can join together to form networks when needed. However, in certain mutations that can cause Parkinson's disease, this cooperation is impaired.
- Sonic hedgehog protein pathway stimulation could help Parkinson's patientson September 22, 2021 at 1:08 pm
Levodopa, or L-dopa, is considered the most effective treatment for Parkinson's disease today. After a few years of treatment, however, almost all patients develop a debilitating side-effect called L-dopa induced dyskinesia, or LID, which causes involuntary movements in the limbs, face, and torso. Deep brain stimulation can alleviate LID, but the procedure is highly invasive and not all patients are eligible.
- Nasal drugs show promise for slowing Parkinson’s disease progression in lab studyon September 21, 2021 at 9:18 pm
Researchers have shown that two lab-developed and nasally-delivered peptides helped slow the spread of alpha-synuclein in mice. 'If these results can be replicated in patients, it would be a remarkable advance in the treatment of devastating neurological disorders,' says the lead author.
- Study rules out an antioxidant treatment for slowing the progression of Parkinson’s diseaseon September 14, 2021 at 4:50 pm
Participants in the SURE-PD3 clinical trial showed that elevating the natural antioxidant urate through inosine treatment over two years produced no significant difference in the rate of Parkinson's disease progression.
- BCL11A: Evidence for neuroprotective effecton September 14, 2021 at 4:49 pm
The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the substantia nigra - a particularly sensitive part of the brain - is what causes the core symptoms of Parkinson's disease. An international team has now investigated the role played by the transcription factor BCL11A in mice and human cells. If this important factor is missing, the neurons are even more sensitive and more likely to die. The researchers suspect that BCL11A plays a protective role for neurons.