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- Get moving to put the brakes on early Parkinson’son January 12, 2022 at 11:13 pm
A new study suggests that people with early-stage Parkinson's disease who regularly got one to two hours of moderate exercise twice a week, like walking or gardening, may have less trouble balancing, walking and doing daily activities later.
- New knowledge about the 'happiness hormone' dopamineon January 11, 2022 at 8:36 pm
New findings provide a better understanding of how the synthesis of dopamine is regulated in the brain. It may shed new light on the mechanism behind diseases such as Parkinson's.
- Parkinson’s protein blueprint could help fast-track new treatmentson December 23, 2021 at 3:14 pm
Researchers have solved a decade-long mystery about a critical protein linked to Parkinson's disease that could help to fast-track treatments for the incurable disease. The research has produced a 'live action' view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it is responsible for initiating the removal and replacement of damaged mitochondria. When the protein is not working correctly, it can starve brain cells of energy, causing them to malfunction and -- in the long term -- die, as happens to dopamine-producing cells in Parkinson's disease. The discovery is the culmination of a project spanning eight years and provides the first detailed blueprint for the discovery and development of therapeutic agents that could help to slow or even stop the progression of Parkinson's disease.
- Parkinson's disease mutation misdirects iron in the brainon December 16, 2021 at 7:50 pm
A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study. The results may help explain the accumulation of toxic iron in affected brain areas in the disease and provide a basis for the development of therapies designed to correct the iron trafficking defect.
- SARS-CoV-2 protein interacts with Parkinson’s protein, promotes amyloid formation, study findson December 14, 2021 at 6:51 pm
Researchers have shown that, at least in the test tube, the SARS-CoV-2 N-protein interacts with a neuronal protein called alpha-synuclein and speeds the formation of amyloid fibrils, pathological protein bundles that have been implicated in Parkinson's disease.